Review Quality Rating: 8 (strong) - View Quality Assessment Citation: Windle,G., Hughes,D., Linck,P., Russell,I., & Woods,B. (2010). Is exercise effective in promoting mental well-being in older age? A systematic review. Aging & Mental Health, 14(6), 652-669. Abstract BACKGROUND: Promoting the mental well-being of older people has been neglected.AIM: To examine the clinical and cost-effectiveness of exercise and physical activity interventions on mental well-being in people aged 65+.DESIGN: Systematic review, meta-analysis, economic model.METHODS: Reports published in English, identified by searching 25 databases, 11 websites and references lists of systematic reviews. Eligible studies were those with a comparison or control group or offering qualitative evidence; exercise and physical activity interventions for people aged 65 and above living at home, in the community, in supported housing or in residential care homes; including outcome measures of mental well-being, not simply measures of depression or anxiety. Low-quality studies were excluded from the data synthesis.RESULTS: An overall effect of exercise on mental well-being was found (standardised effect size = 0.27; CI = 0.14-0.40). The included interventions were designed for older people, targeted those who are sedentary and delivered in a community setting, primarily through a group-based approach led by trained leaders. As a minimum, the evidence would suggest two exercise sessions per week, each of 45 min duration. There is some indication that exercise can also improve the mental well-being of frail elders. Economic evidence indicated incremental cost-effectiveness ratios (compared with minimal intervention) of pound7300 and pound12,100 per quality adjusted life year gained for community-based walking and exercise programmes, respectively.CONCLUSIONS: Mental well-being in later life is modifiable through exercise and physical activity. To generalise the findings, there is a need for more evidence of effectiveness from older people in the UK. Keywords: Behaviour Modification, Community, Economic Evaluation, Education, Awareness & Skill Development or Training, Home, Men, Mental Health & Wellness, Meta-analysis, Older Adults, Physical Activity, Senior Health, Social Support, Women